Background

The Clinical Breast Care Project (CBCP) is the outcome of the initial FY00 and subsequent Congressional appropriations, and consists of an extensive collaborative effort between Windber Research Institute (Windber, PA – 12th Congressional District of the Honorable John P. Murtha) and Walter Reed Army Medical Center (now WRNMMC), with funding management by the Henry M. Jackson Foundation for the Advancement of Military Medicine. The Clinical Breast Care Project (CBCP) was created using these five pillars 1) Translational Clinical Care 2) Breast Cancer Risk Reduction 3) Biorepository 4) Focused Research 5) Biomedical Informatics.

The primary role of the CBCP is to conduct research: collection of confidential (normalized) patient information, specimen (tissue, blood, bone marrow, etc.) acquisition, risk reduction, protocol administration and project administration. The Risk Reduction Clinic provides genetic counseling and monitoring of high risk breast cancer patients.

The project centered around two human use clinical trials/protocols:

  1. Tissue and Blood Library establishment for Molecular, Biochemical and Histologic Study of Breast Disease
  2. Creation of a Blood Library for the Analysis of Blood for Molecular Changes Associated with Breast Disease and Breast Cancer Development

Objectives for the above human use clinical trials are:

  1. Acquisition and banking of breast tissue, lymph nodes, and/or blood from informed and consenting donors
  2. Experimental analysis of DNA, RNA and/or proteins isolated from donor tissues for molecular, biochemical, and/or histopathological analysis
  3. Establishment of an integrated and relational database for tissue/serum and patient clinical characteristics that will provide the resources necessary to achieve the following future goals
  4. Establishing a repository of high quality breast tissue and related (lymph nodal, blood) specimens for research on breast cancer and associated breast diseases
  5. Permitting the establishment of a single relational database with accurate and comprehensive biologically and clinically relevant information on breast diseases.